Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：BMC Neurology

Publication type: Article

IF(IF): 2.9

PMID: 36709260 Link To Pubmed Full text Download

Extension of hemorrhage into the subarachnoid space (SAHE) is sometimes observed simultaneously in primary ICH. Previous studies have found that SAHE is associated with poor outcomes in primary ICH patients and hematoma expansion in lobar ICH. The mechanism is unclear. Our study aims to investigate whether SAHE is independently associated with poor outcomes in patients with supratentorial ICH.

Our study is a retrospective analysis using data from the prospective, multicenter, observational, registry-based study in Beijing, China. The inclusion criteria are listed as follows: (1) Supratentorial ICH was diagnosed by the WHO standard and confirmed by each hospital’s computerized tomography (CT) scan; (2) with the age ≥18 years old; (3) arriving at emergency and performed CT scan within 72 hours after symptoms onset; (4) written consent was obtained. The exclusion criteria include the following: (1) known major comorbidities or late-stage diseases, such as liver failure, end-stage kidney diseases, heart failure and malignant tumor; (2) first-ever acute-onset ICH; (3) congenital or obtained coagulation disorders confirmed by imaging or laboratory tests (4) severe missing of follow-up outcomes. First, we will describe and compare baseline characteristics between two groups with and without SAHE. Second, we will compare the prognosis such as death and mRS between two groups. Finally, the regression model will be built to determine the association between baseline SAHE and poor outcomes at discharge, 1 month, 3 months and 1 year.