Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：CNS Neuroscience & Therapeutics

Publication type: Original Contributions

IF(IF): 7.035

PMID: 36415111 Link To Pubmed Full text Download

Magnesium, the second most predominant intracellular cation, is an essential trace element involved in processes that regulates cardiovascular function through vascular tone, blood pressure, endothelial function, platelet aggregation and coagulation, cardiac arrhythmias, and glucose and insulin metabolism[1-3]. Relevant laboratory evidence showed that low serum magnesium was associated with inflammation[4] and disturbances in the regulation of vascular tone and endothelial function[5],which enhance atherosclerotic changes and arterial stiffness[6]. Previous epidemiological studies also reported chronic magnesium deficiency can be associated to increased risk of type 2 diabetes mellitus, metabolic syndrome arterial hypertension, and cardiovascular disease [7-10]. Although some previous studies have addressed the relationship between serum magnesium and stroke, but with conflicting results [11]. Limited data is available about the relationship between serum magnesium level and ischemic stroke outcomes. In this study, we aimed to estimate the association between serum magnesium levels and clinical outcomes after AIS or transient ischemic attack (TIA), including all-cause mortality, poor functional outcome, stroke recurrence, and composite vascular events at 3- and 12- months.

Participants were classified into 4 groups based on the quartile of serum magnesium levels. Univariate and multivariate analysis were used to examine the association between each exposure and multiple outcomes, including all-cause mortality, stroke recurrence, poor functional outcome, and composite vascular events at 3- and 12 months, respectively. Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for the association of the exposures with mortality, stroke recurrence, and composite vascular events. The Kaplan-Meier product-limit technique was used to estimate survival curves, and a log-rank test was used to compare survival curves for those outcomes. Logistic model was used to calculate Odds ratios (ORs) with 95% CIs for the association of the exposures with poor functional outcomes. Additionally, we used the restricted cubic spline to evaluate the nonlinear relationship. Subgroup analysis was performed according to age, sex, BMI, smoking, alcohol drinking, initial stroke severity accessed by NIHSS score on admission and etiology of stroke with an interaction test.