Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Associations of deep medullary veins with vascular risk factors, laboratory indicators, and cerebral small vessel disease: A population-based study
First author：Yu Tian,Shan Li
Corresponding author：Yuesong Pan; Yilong Wang
essential_information
- Person in charge：Yu Tian,Shan Li
- Data Sources： PRECISE
- Number of papers：PRECISE20220054
- Published time：2023-04-09
2023-04-09
Published articles
Journal：Brain Behav
Publication type: Original Contributions
IF(IF): 3.405
PMID: 37032510 Link To Pubmed Full text Download
Background And Purpose
1
Method
General linear regression was used to assess the potential risk factors for DMVs score. And logistics regression was used to assess the association between DMVs score with CSVD burden and neuroimaging markers of CSVD.
Conclusion
Several conventional vascular factors were associated with DMVs. The relationship between DMVs and CSVD was vulnerable, suggesting decreased visible and discontinuous DMVs may differ mechanistically from traditional markers of CSVD.
Main results
Mean age was 61.8 (SD 6.5) years, and 1027 (53.8%) of participants were men. The median DMV scores were14 (IQR 12-16). DMV scores wererelated to age, male sex, body mass index, diastolic blood pressure, hypercholesterolaemia, atrial fibrillation, current drinking, total cholesterol, triglycerides, low-density lipoprotein, hemoglobin A1c, leukocytes, lymphocytes, hemoglobin, and platelets (p < .05). DMV scores wereassociated with the presence and total burden of CSVD (Rothwell's scale), modified white matter hyperintensity burden, and enlarged perivascular spaces in centrum semiovale (p < .05). However, these associations between DMV scores and CSVD disappeared after adjusting for potential confounders.