Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Acute-phase heart rate trajectories and functional outcomes in acute ischemic stroke
First author：Zhiyuan Feng,Huibing Qin,Yijun Zhang
Corresponding author：Yongjun Wang
essential_information
- Person in charge：Zhiyuan Feng,Huibing Qin,Yijun Zhang
- Data Sources： BOSS
- Number of papers：BOSS20220066
- Published time：2022-03-10
2022-03-10
Published articles
Journal：Journal Of Clinical Hypertension
Publication type: Original Contributions
IF(IF): 2.885
PMID: 35274456 Link To Pubmed Full text Download
Background And Purpose
The heart rate (HR) trajectory is a dynamic metric that shows how HR changes over time. Previous studies have demonstrated that elevated HR is associated with stroke events. However, little research has been done on the influence of shifting HR throughout the acute period on clinical outcomes. This study aims to investigate the effect of HR trajectories on functional outcomes in patients with acute ischemic stroke (AIS).
Method
A total of 981 AIS patients were included in the study. A latent mixture model was used to assess HR trends over the first 7 days following disease onset. The patients were divided into four groups based on different HR trajectories: markedly decreasing in 48 h (T1), mildly decreasing in 48 h (T2), sustained moderate in 7 days (T3), and sustained high in 7 days (T4). Poor outcome was defined as a modified Rankin Scale (mRS) score of ≥3 in 3 months. Logistic regression was used to analyze the correlation between different HR trajectories and outcomes.
Conclusion
This suggests that in AIS patients, a sustained high HR trajectory is linked to a greater likelihood of poor functional outcome than a markedly decreasing HR trajectory. HR trajectories demonstrate the utility of repeated HR measurements for outcome assessment.
Main results
The incidence of poor outcomes was 9.02%, 10.80%, 11.79%, 16.36% in T1 (n = 133), T2 (n = 352), T3 (n = 441), and T4 (n = 55) groups, respectively. Compared with T1 group, T4 group was significantly associated with a higher risk of poor outcome at 3 months (odds ratio = 3.00, 95% confidence interval = 1.06–8.54, p value = .0392).