Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Slightly Elevated Lymphocyte to Monocyte Ratio Predicting Favorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage
First author：Jinjin Wang,Wenjuan Wang
Corresponding author：Xingquan Zhao, Jingjing Lu
essential_information
- Person in charge：Jinjin Wang,Wenjuan Wang
- Data Sources：
- Number of papers：脑出血登记20220106
- Published time：2022-12-16
2022-12-16
Published articles
Journal：Journal of inflammation research
Publication type: Article
IF(IF): 4.2
PMID: 36560932 Link To Pubmed Full text Download
Background And Purpose
Intracerebral hemorrhage (ICH) is one common yet disproportionately deadly stroke subtype. Inflammation and immune response exert a vital role in the secondary injury after intracerebral hemorrhage. Therefore, our study aims to investigate the prognostic value of systemic immune–inflammation index (SII) for clinical outcomes after ICH.
Method
We used a prospective and registry-based database, and ICH patients were consecutively recruited in Beijing Tiantan Hospital between January 2014 and September 2016. All participants were stratified by quartiles of the LMR. Univariable and multivariable logistic regression analyses were plotted to evaluate the association between LMR levels and functional outcomes. Kaplan-Meier survival curves and Cox regression analysis were also performed to examine the relevance between different LMR quartiles and case fatality at follow-up.
Conclusion
This study suggests that a lower LMR value is associated with higher risks of in-hospital infections, poor functional outcomes, and follow-up mortality in patients with ICH. However, a slightly elevated LMR value, especially in Q2, relates to a favorable prognosis, which may reflect an inner balance between inflammation and immunodepression and thus provides a promising marker for predicting ICH prognosis.
Main results
Six hundred and forty patients with spontaneous ICH were finally included in this study. Compared with the patients with LMR values in quartile 1 (Q1), slightly elevated LMR values showed a negative correlation with risks of poor short-term outcomes (adjusted ORs in Q2 were 0.572 [95% CI: 0.338-0.968] at 1 month, 0.515 [95% CI: 0.305-0.871] at 3 months). Patients with LMR values in Q1 had the highest cumulative death rate. A slightly elevated LMR was also independently relevant to a deduced mortality rate compared to that in Q1 (adjusted HRs in Q2 were 0.471 [95% CI: 0.274-0.809] at 1 month, 0.474 [95% CI: 0.283-0.793] at 3 months, 0.575 [95% CI: 0.361-0.917] at 1 year). Additionally, a higher LMR value was associated with a lower risk of in-hospital infections.