国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of β-cell function and cognitive impairment in patients with abnormal glucose metabolism

第一作者：Mengyi Guo

通讯作者：Xingquan Zhao,Shengyun Chen

Alzheimer’s disease Cognitive impairment Diabetes HOMA-β β-Cell function

基本信息

  • 负责人：Mengyi Guo
  • 数据来源： OTHERS
  • 论文编号：OTHERS20220138
  • 发表时间：2022-06-23

2022-06-23

已发表文章

发表杂志：BMC Neurology

发表类型: Original Contributions

影响因子(IF): 2.903

PMID: 35739484 Pubmed原文链接 全文下载

主要研究背景及目的

Insulin has been demonstrated to play an important role in the occurrence and development of Alzheimer's disease, especially in those with diabetes. β cells are important insulin-producing cells in human pancreas. This study aimed to investigate the association between β-cell dysfunction and cognitive impairment among patients over 40-year-old with abnormal glucose metabolism in Chinese rural communities.

方法

A sample of 592 participants aged 40 years or older from the China National Stroke Prevention Project (CSPP) between 2015 and 2017 were enrolled in this study. Abnormal glucose metabolism was defined when hemoglobin Alc ≥ 5.7%. Cognitive function was assessed by the Beijing edition of the Montreal Cognitive Assessment scale. Homeostasis assessment of β-cell function was performed and classified into 4 groups according to the quartiles. A lower value of HOMA-β indicated a worse condition of β-cell function. Multivariate logistic regression was used to analyze the association between β-cell function and cognitive impairment.

结论

Our study showed that worse β-cell function is associated with cognitive impairment of people over 40-year-old with abnormal glucose metabolism in Chinese rural communities, especially in the cognitive domains of abstraction and language.

主要结果

In a total of 592 patients with abnormal glucose metabolism, the average age was 60.20 ± 7.63 years and 60.1% patients had cognitive impairment. After adjusting for all potential risk factors, we found the first quartile of β-cell function was significantly associated with cognitive impairment (OR: 2.27, 95%CI: 1.32-3.92), especially at the domains of language (OR: 1.64, 95%CI: 1.01-2.65) and abstraction (OR: 2.29, 95%CI: 1.46-3.58).