国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association between triglyceride glucose index and atherosclerotic plaque and burden: findings from a community-based study
通讯作者：Yuesong Pan
基本信息
- 负责人：Mengxing Wang,Lerong Mei
- 数据来源： PRECISE
- 论文编号：PRECISE20220143
- 发表时间：2022-10-11
2022-10-11
已发表文章
主要研究背景及目的
Insulin resistance (IR), as a risk factor of metabolic diseases, could contribute to the development of cardiovascular disease and was associated with an increased stroke risk. The atherosclerosis is the main pathological cause of cardiovascular disease and stroke. Previous studies have reported an association between insulin resistance and early arteriosclerotic lesions. Some studies have shown that the triglycerides-glucose (TyG) index has a better value for assessing insulin resistance than homeostatic insulin resistance (HOMA-IR) model. The TyG index was more closely related to coronary artery stenosis and calcification relative to HOMA-IR, but few studies have focused on their relationship with the comprehensive atherosclerotic burden and plaques, especially in intra- and extracranial arteries. Therefore, we aimed to investigate the association of the TyG index with atherosclerotic burden and plaques in coronary, intra- and extracranial arteries in participants with non-diabetes and compared the results with that of HOMA-IR.
方法
The association of insulin resistance with atherosclerosis was analyzed by binary logistic regressions and ordinal logistic regression models.
结论
Elevated TyG index was associated with increased odds of atherosclerosis in coronary/intra- and extracranial arteries. Compared with HOMA-IR, the TyG index was more strongly associated with intracranial atherosclerosis. Moreover, discordantly high TyG index with HOMA-IR was also important for atherosclerosis identification.