Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Cardiovascular Diabetology

Publication type: Article

IF(IF): 8.949

PMID: 36221073 Link To Pubmed Full text Download

Insulin resistance (IR), as a risk factor of metabolic diseases, could contribute to the development of cardiovascular disease and was associated with an increased stroke risk. The atherosclerosis is the main pathological cause of cardiovascular disease and stroke. Previous studies have reported an association between insulin resistance and early arteriosclerotic lesions. Some studies have shown that the triglycerides-glucose (TyG) index has a better value for assessing insulin resistance than homeostatic insulin resistance (HOMA-IR) model. The TyG index was more closely related to coronary artery stenosis and calcification relative to HOMA-IR, but few studies have focused on their relationship with the comprehensive atherosclerotic burden and plaques, especially in intra- and extracranial arteries. Therefore, we aimed to investigate the association of the TyG index with atherosclerotic burden and plaques in coronary, intra- and extracranial arteries in participants with non-diabetes and compared the results with that of HOMA-IR.

The association of insulin resistance with atherosclerosis was analyzed by binary logistic regressions and ordinal logistic regression models.