国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study
第一作者：Yu Tian, Xueli Cai
基本信息
- 负责人：Yu Tian, Xueli Cai
- 数据来源： PRECISE
- 论文编号：PRECISE20220156
- 发表时间：2023-04-12
2023-04-12
已发表文章
主要研究背景及目的
The glymphatic system is essential to maintaining brain health in humans. However, little is known about the role of glymphatic function and its association with cerebral small vessel disease among the community-dwelling population.
方法
All baseline characteristics were compared among individuals with absent CSVD and present CSVD according to total CSVD burden described by Wardlaw et al. and modified total CSVD burden described by Rothwell et al., respectively. DTI-ALPS index was assessed for associations with presence, severity and neuroimaging markers of CSVD as a continuous variable (per 1-SD decrement) and according to quartiles as follows: quartile 1(Q1): <1.57; quartile 2(Q2): 1.57-1.65; quartiles 3(Q3): 1.66-1.76; quartiles 4(Q4): ≥1.76. Binary logistics regression models were performed for the relationships of DTI-ALPS index with presence of CSVD, lacunes, CMBs, WMH burden, EPVS, and BA. Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated. Ordinal logistics regression models were performed for the relationships of DTI-ALPS index with total CSVD burden, modified total CSVD burden, modified WMH burden, and CMBs burden. Common ORs(cORs) and their 95% CIs were calculated.
结论
A lower DTI-ALPS index underlay the presence, severity and typical neuroimaging markers of CSVD, implying that glymphatic impairment may interact with CSVD-related pathology in the general ageing population.