Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Stroke Vasc Neurol

Publication type: Original Contributions

IF(IF): 9.89

PMID: 37045543 Link To Pubmed Full text Download

The glymphatic system is essential to maintaining brain health in humans. However, little is known about the role of glymphatic function and its association with cerebral small vessel disease among the community-dwelling population.

All baseline characteristics were compared among individuals with absent CSVD and present CSVD according to total CSVD burden described by Wardlaw et al. and modified total CSVD burden described by Rothwell et al., respectively. DTI-ALPS index was assessed for associations with presence, severity and neuroimaging markers of CSVD as a continuous variable (per 1-SD decrement) and according to quartiles as follows: quartile 1(Q1): <1.57; quartile 2(Q2): 1.57-1.65; quartiles 3(Q3): 1.66-1.76; quartiles 4(Q4): ≥1.76. Binary logistics regression models were performed for the relationships of DTI-ALPS index with presence of CSVD, lacunes, CMBs, WMH burden, EPVS, and BA. Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated. Ordinal logistics regression models were performed for the relationships of DTI-ALPS index with total CSVD burden, modified total CSVD burden, modified WMH burden, and CMBs burden. Common ORs(cORs) and their 95% CIs were calculated.