Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Soluble lectin-like oxidized low-density Lipoproteinreceptor-1 and recurrent stroke: A nested case-control study
First author：Anxin Wang,Xue Tian,Jie Xu
Corresponding author：Xia Meng,Yongjun Wang
essential_information
- Person in charge：Anxin Wang,Xue Tian,Jie Xu
- Data Sources： CNSR-Ⅲ
- Number of papers：CNSR-Ⅲ20220161
- Published time：2022-07-31
2022-07-31
Published articles
Journal：CNS Neuroscience & Therapeutics
Publication type: Original Contributions
IF(IF): 7.035
PMID: 35909324 Link To Pubmed Full text Download
Background And Purpose
The prognostic value of soluble lectin-like oxidized low-density lipoproteinreceptor-1 (sLOX-1) for stroke was unclearly. This study aimed to investigate the association between sLOX-1 and recurrent stroke in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).
Method
Data were obtained from the Third China National Stroke Registry. Eligible cases consisted of 400 patients who developed recurrent stroke within 1-year followup, 800 controls were selected using age- and sex-matched with a 1:2 case–control ratio. Conditional logistic regressions were used to evaluate the association between sLOX-1 and recurrent stroke.
Conclusion
sLOX-1 was positively associated with the risk of recurrent stroke, which may be a candidate biomarker to improve risk stratification of recurrent stroke.
Main results
Among 1200 patients included in this study, the median (interquartile range) of sLOX-1 was 247.12 (132.81–413.58) ng/L. After adjustment for conventional confounding factors, the odds ratio with 95% confidence interval in the highest tertile versus the lowest tertile was 2.23 (1.61–3.08) for recurrent stroke, 2.31 (1.64–3.24) for ischemic stroke, 2.30 (1.66–3.19) for combined vascular events within 1-year follow-up. Furthermore, the addition of sLOX-1 to a conventional risk model had an incremental effect on predictive value for recurrent stroke (C-statistics 0.76, p< 0.0001; integrated discrimination improvement 13.38%, p< 0.0001; net reclassification improvement 55.39%, p< 0.0001). Similar results were observed when the timepoint was set up as 3 months. Subgroup analysis showed the association between higher sLOX-1 and recurrent stroke was more pronounced in patients with a history of stroke (p for interaction = 0.0062).