Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：SVN

Publication type: Original Contributions

IF(IF): 5.9

PMID: 38365316 Link To Pubmed Full text Download

Atrial Fibrillation Detected After Stroke (AFDAS) is a concept brought up in 2017, which may comprise a heterogeneous mix of AF phenotypes including cardiogenic and neurogenic types, as well as a combination of both. To date, studies on AFDAS mostly focused on ischemic stroke. Several studies demonstrated that compared to patients with known atrial fibrillation (KAF), the AFDAS population has a reduced prevalence of cardiovascular comorbidities, but studies are discordant with regards to the prognosis of AFDAS, KAF and sinus rhythm. Hemorrhagic stroke, including ICH and SAH, also have impact on automatic and inflammatory responses, which are the major potential mechanisms of AFDAS. Data regarding AFDAS in hemorrhagic stroke are lacking. Understanding the prevalence, risk factors and prognosis value of AFDAS in different stroke types may give us insight into the mechanisms of AFDAS and guide future therapeutic strategies. Therefore, we aim to compare the prevalence, risk factors and in-hospital prognostic values of AFDAS after hemorrhagic versus ischemic stroke.

Patients with hemorrhagic or ischemic stroke from the Chinese Stroke Center Alliance program were enrolled. Patients were divided into hemorrhagic stroke (intracerebral hemorrhage, subarachnoid hemorrhage) and ischemic stroke. Based on their history of AF and discharge diagnosis, patients can be stratified into 3 groups: AFDAS, KAF and sinus rhythm. The prevalence and risk factors of AFDAS were compared between different stroke types. Multivariable logistic regression was used to assess the impact of AFDAS on in-hospital mortality in different stroke types.