国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

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Joint High Level of Oxidized Low-Density Lipoprotein and High-Sensitivity C-Reactive Protein are Associated With Recurrent Stroke and Poor Functional Outcome in Minor Stroke or Transient Ischemic Attack

第一作者：Qin Xu,Qiong Wu

通讯作者：Anxin Wang,Xia Meng

oxidized low-density lipoprotein high-sensitive C-reactive protein recurrent stroke poor functional outcome stroke

基本信息

  • 负责人：Qin Xu,Qiong Wu
  • 数据来源： CHANCE
  • 论文编号：CHANCE20220195
  • 发表时间：2022-10-07

2022-10-07

已发表文章

发表杂志：Journal of the American Heart Association

发表类型: Original Contributions

影响因子(IF): 6.106

PMID: 36205258 Pubmed原文链接 全文下载

主要研究背景及目的

Oxidized low-density lipoprotein (oxLDL) and high-sensitive C-reactive protein (hs-CRP) plays an important role in cardiovascular diseases though inflammation and oxidative stress, etc. However, evidence on their combined effects on stroke prognosis is still limited. We aimed to explore the joint association of oxLDL and hs-CRP with outcomes of minor stroke or transient ischemic attack (TIA).

方法

A subgroup of 3019 patients from the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were analyzed. Baseline oxLDL and hs-CRP levels were measured. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year, and ischemic stroke, combined vascular events, and poor functional outcomes (modified Rankin Scale [mRS] 2-6 or 3-6) at 90 days and 1 year. Vascular events outcomes were analyzed with Cox proportional hazards and poor functional outcomes with logistic models.

结论

In patients with minor stroke or TIA, joint high levels of oxLDL and hs-CRP was associated with increased risk of recurrent stroke, combined vascular events, and poor functional outcome.

主要结果

Elevated oxLDL (> 28.81 μg/dL) and hs-CRP (> 4.20 mg/L) was observed in 624 (20.67%) of the 3019 patients. Patients with oxLDL > 28.81 μg/dL and hs-CRP > 4.20 mg/L had a higher risk of recurrent stroke within 90 days (adjusted hazard ratio,1.52; 95% confidence interval, 1.17-1.97), compared with those with oxLDL ≤ 28.81 μg/dL and hs-CRP ≤ 4.20 mg/L, after adjusting relevant confounding factors (P = 0.002). Similar results were observed for secondary outcomes (P < 0.05 for all).