Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Joint High Level of Oxidized Low-Density Lipoprotein and High-Sensitivity C-Reactive Protein are Associated With Recurrent Stroke and Poor Functional Outcome in Minor Stroke or Transient Ischemic Attack
First author：Qin Xu,Qiong Wu
Corresponding author：Anxin Wang,Xia Meng
essential_information
- Person in charge：Qin Xu,Qiong Wu
- Data Sources： CHANCE
- Number of papers：CHANCE20220195
- Published time：2022-10-07
2022-10-07
Published articles
Journal：Journal of the American Heart Association
Publication type: Original Contributions
IF(IF): 6.106
PMID: 36205258 Link To Pubmed Full text Download
Background And Purpose
Oxidized low-density lipoprotein (oxLDL) and high-sensitive C-reactive protein (hs-CRP) plays an important role in cardiovascular diseases though inflammation and oxidative stress, etc. However, evidence on their combined effects on stroke prognosis is still limited. We aimed to explore the joint association of oxLDL and hs-CRP with outcomes of minor stroke or transient ischemic attack (TIA).
Method
A subgroup of 3019 patients from the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were analyzed. Baseline oxLDL and hs-CRP levels were measured. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year, and ischemic stroke, combined vascular events, and poor functional outcomes (modified Rankin Scale [mRS] 2-6 or 3-6) at 90 days and 1 year. Vascular events outcomes were analyzed with Cox proportional hazards and poor functional outcomes with logistic models.
Conclusion
In patients with minor stroke or TIA, joint high levels of oxLDL and hs-CRP was associated with increased risk of recurrent stroke, combined vascular events, and poor functional outcome.
Main results
Elevated oxLDL (> 28.81 μg/dL) and hs-CRP (> 4.20 mg/L) was observed in 624 (20.67%) of the 3019 patients. Patients with oxLDL > 28.81 μg/dL and hs-CRP > 4.20 mg/L had a higher risk of recurrent stroke within 90 days (adjusted hazard ratio,1.52; 95% confidence interval, 1.17-1.97), compared with those with oxLDL ≤ 28.81 μg/dL and hs-CRP ≤ 4.20 mg/L, after adjusting relevant confounding factors (P = 0.002). Similar results were observed for secondary outcomes (P < 0.05 for all).