Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Clinical and Experimental Hypertension

Publication type: Research Article

IF(IF): 12.3

PMID: 36471901 Link To Pubmed Full text Download

Elevated blood pressure (BP) is the most important modifiable risk factor for acute stroke. Recently, an abundance of studies have found that certain BP profiles acquired by ambulatory blood pressure monitoring (ABPM), such as non- and reverse dipping patterns, predicted increased hypertensive target organ damage and poor cardiovascular prognosis in general as well as in hypertensive populations. there was considerable controversy surrounding the prognostic value of dipping patterns in patients with acute ischemic stroke (IS) or transient ischemic attack (TIA). Furthermore, there is a paucity of data from large stroke cohort studies. Therefore, we investigated the relationship between dipping patterns early after acute IS/TIA onset and 1-year stroke functional outcome in a large cohort study.

Data from the Blood Pressure and Clinical Outcome in TIA or Ischemic Stroke Study (BOSS), a nationwide, hospital-based, longitudinal cohort study, was used for this study. Patients with acute IS or TIA were recruited within 7 days after onset and ambulatory blood pressure monitoring was performed during hospitalization. Patients were defined as dippers if nocturnal systolic blood pressure fell by ≥10%, non-dippers if 0–10%, and reverse dippers if < 0%. Poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3–5. Logistic regression analysis was used to test the association between dipping patterns and 1-year functional outcome.