Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Prediction of H3 K27M-mutant in midline gliomas by magnetic resonance imaging: a systematic review and meta-analysis
First author：Tiantian Hua, Zhizheng Zhuo
Corresponding author：Liwei Zhang, Yaou Liu
essential_information
- Person in charge：Tiantian Hua, Zhizheng Zhuo
- Data Sources： OTHERS
- Number of papers：OTHERS20230019
- Published time：2022-04-13
2022-04-13
Published articles
Journal：Neuroradiology
Publication type: Research Article
IF(IF): 2.995
PMID: 35416485 Link To Pubmed Full text Download
Background And Purpose
To summarize the predictive value of MRI for H3 K27M-mutant in midline gliomas using meta-analysis
Method
Systematic electronic searches of the PubMed, Embase, ISI Web of Science, and Cochrane Library up to Jun 31, 2021, were conducted by two experienced neuroradiologists with the keywords of “MRI,” “Glioma,” and “H3 K27M.” The hierarchical summary receiver-operating characteristic (HSROC) model was used to calculate the pooled sensitivity, specifcity, positive likelihood ratio (LR+), negative likelihood ratio (LR−), and diagnostic odds ratio (DOR). Coupled forest plots were used to evaluate the heterogeneity of the included studies.
Conclusion
This meta-analysis demonstrated a clinical value of MRI to predict H3 K27M-mutant in midline gliomas with a pooled sensitivity of 0.78 and specifcity of 0.85.
Main results
Of seven original studies with a total of 593 patients, 240 glioma patients were included, with 45.5–70.6% H3 K27Mmutant gliomas. Using MRI, a pooled sensitivity of 0.78 (95% CI, 0.66–0.87), specifcity of 0.85 (95% CI, 0.76–0.91), LR+of 5.07 (95% CI, 3.19–8.08), LR−of 0.26 (95% CI, 0.16–0.42), and DOR of 19.80 (95% CI, 9.28–42.28) were achieved for H3 K27M-mutant prediction. Signifcant heterogeneity was observed among the studies in terms of sensitivity (Q=16.83, df=7, p=0.02; I2=58.40 [95% CI, 25.83–90.97]), LR−(Q=16.61, df=7, p=0.02; I2=57.87 [95% CI, 24.81–90.93]), and DOR (Q=14.05, df=7, p=0.05; I2=50.18 [95% CI, 10.06–90.31]).