Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Associations of Life’s Essential 8 with extent of multi-territorial atherosclerotic plaques and stenosis
First author：Yanli Zhang； Dandan Liu
Corresponding author：Yuesong Pan；Yongjun Wang
essential_information
- Person in charge：Yanli Zhang； Dandan Liu
- Data Sources： PRECISE
- Number of papers：PRECISE20230086
- Published time：2024-06-07
2024-06-07
Published articles
Journal：BMC Geriatrics
Publication type: Original Article
IF(IF): 4.1
PMID: 38844834 Link To Pubmed Full text Download
Background And Purpose
Life’s Essential 8 (LE8), the recently updated construct for quantifying cardiovascular health, is related to the risks of cardiovascular events. The present study aimed to evaluate associations of LE8 score with the multi-territorial extent of atherosclerosis in a community-dwelling population.
Method
Data were derived from the baseline cross-sectional survey of the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study in Lishui City. The LE8 included overall, medical and behavior LE8 scores, and categorized as low (<60), moderate (60-<80), and high (≥80) groups. Vascular magnetic resonance imaging was used to evaluate intracranial and extracranial arteries; thoracoabdominal computed tomography angiography to evaluate coronary, subclavian, aorta, renal, ilio-femoral arteries; and ankle-brachial index to evaluate peripheral arteries. The presence of atherosclerotic plaque or stenosis in any territory was defined as plaque or vascular stenosis with 1 territory affected or more in these arteries. The extent of atherosclerotic plaques or stenosis was assessed according to the number of these 8 vascular sites affected, and graded as four grades (none, single territory, 2-3 territories, 4-8 territories).
Conclusion
The higher LE8 scores, indicating healthier lifestyle, were associated with lower presence and extent of atherosclerotic plaque and stenosis in southern Chinese adults. Prospective studies are needed to further validate these findings.
Main results
Of 3065 included participants, the average age was 61.2±6.7 years, and 53.5% were women (n=1639). The moderate and high overall LE8 groups were associated with lower extent of multi-territorial plaques [common odds ratio (cOR) 0.44, 95% confidence interval (CI), 0.35-0.55; cOR 0.16, 95%CI, 0.12-0.21; respectively] and stenosis (cOR 0.51, 95%CI, 0.42-0.62; cOR 0.16, 95%CI, 0.12-0.21; respectively) after adjustment for potential covariates. Similar results were observed for medical LE8 score with the extent of multi-territorial plaques and stenosis (P <0.05). We also found the association between behavior LE8 score and the extent of multi-territorial stenosis (P <0.05).