Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：Current Neurovascular Research

Publication type: Article

IF(IF): 1.7

PMID: 39757632 Link To Pubmed Full text Download

Previous studies have indicated that there may be differences in functional outcomes based on the site of hemorrhage, and uncertainty surrounds the prognosis of deep brain and lobar ICH. As a result of the incomplete identification of hemorrhage characteristics by ICH location, acute treatment and monitoring in patients with deep versus lobar ICH locations do not fundamentally differ. We hypothesized that including the cause of ICH, the location of lobar hemorrhage, comorbidities, medical complications, and hematoma evolution would be significantly associated with improved prediction of 1-year recovery among patients of lobar ICH compared with models using only baseline characteristics. The main objective of this study is to investigate the occurrence rate of adverse functional outcomes in patients with supratentorial lobar hemorrhage and explore the relevant factors that may impact prognosis. Additionally, the study aims to assess the incidence of recurrence and mortality during the follow-up period, providing valuable insights into the overall prognosis and management of lobar hemorrhage.

Inclusion Criteria:(1） age≥18. (2) Diagnosis of primary intracerebral hemorrhage （ICH） within 72 hours from symptom onset and confirmed by computerized tomography （CT） scan. (3) Initial hemorrhage located in the cerebral lobe. (4) Availability of high-quality baseline and CT scan images. Exclusion Criteria: (1) Secondary intracranial hemorrhage caused by trauma, vascular malformation, tumor, or any other suspected secondary cause of ICH. (2) Primary intraventricular hemorrhage. (3) Missing imaging data. (4) Hemorrhagic transformation of ischemic stroke. (5) Missing 1-year modified Rankin Scale (mRS) follow-up data. We plan to use the Wilcoxon rank sum test or t test for continuous variables and χ2 test or Fisher exact test for categorical variables. Multivariable logistic regression evaluates the association between variables of interest prior to day 30 and 1-year good outcome for each trial independently and for the combined cohort.