国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Associations of non-insulin-based insulin resistance indices with presence and extent of multi-territorial atherosclerosis: a cross-sectional study

第一作者：Yanli Zhang,Mengxing Wang

通讯作者： Yuesong Pan

Atherosclerosis; Insulin resistance; TyG index; TyG-BMI index; TG/HDL-C ratio; METS-IR index

基本信息

2024-10-03

已发表文章

发表杂志：Journal of clinical Lipidology

发表类型: Original Article

影响因子(IF): 3.6

PMID: 39537507 Pubmed原文链接 全文下载

主要研究背景及目的

Non-insulin-based insulin resistance (IR) indices, simple and reliable surrogates for IR calculated without insulin level, have been reported to be associated with cardiovascular and cerebrovascular diseases. We aimed to investigate the association of non-insulin-based IR indices with multi-territorial atherosclerosis.

方法

Participants without diabetes from the cross-sectional survey of the PRECISE (Poly-Vascular Evaluation for Cognitive Impairment and Vascular Events) cohort study were included in present study. Non-insulin-based IR indices, including triglyceride and glucose (TyG) index, triglyceride glucose-body mass (TyG-BMI) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) index, were calculated and stratified into quartiles. Intracranial and extracranial arteries were assessed by vascular magnetic resonance imaging, coronary, subclavian, aorta, renal, and ilio-femoral arteries by thoracoabdominal computed tomography angiography, and peripheral arteries by ankle-brachial index. The presence and extent of atherosclerosis were assessed by the number of 8 vascular sites affected.

结论

Elevated non-insulin-based IR indices levels were associated with an increased risk of presence and extent of atherosclerotic plaques and stenosis in non-diabetic, older individuals in the PRECISE study. Further, these IR surrogate markers have certain predictive performance to assess the risk of multi-territorial atherosclerosis.

主要结果

Of 2759 included participants, the average age was 60.9 (±6.6) years, and 1460 (52.9%) were female. Compared with the first quartile of TyG index, the fourth quartile of TyG index was associated with an increased presence and extent of atherosclerotic plaques (OR, 3.51; 95%CI,1.30-1.87; cOR, 2.22; 95%CI,1.76-2.79) and presence and extent of atherosclerotic stenosis (OR, 1.60; 95%CI,1.24-2.06; cOR, 1.66; 95%CI,1.30-2.12). Such associations were also observed for the relationship of TyG-BMI index, TG/HDL-C ratio, and METS-IR index with the presence and extent of atherosclerotic plaques and stenosis. Addition of 4 non-insulin-based IR indices to the basic model with traditional risk factors improved the predictive performance of the presence of atherosclerotic plaque and stenosis.