国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Baseline and longitudinal cardiovascular health using Life's Essential 8 metrics with the risk of incident hypertension

第一作者：Xue Tian ,Jingxuan Feng

通讯作者：Anxin Wang

Life’s Essential 8 cardiovascular health cohort study hypertension longitudinal association

基本信息

2023-11-30

已发表文章

发表杂志：CLINICAL AND EXPERIMENTAL HYPERTENSION

发表类型: Original Contributions

影响因子(IF): 12.3

PMID: 37983187 Pubmed原文链接 全文下载

主要研究背景及目的

The quantification of cardiovascular health (CVH) was updated by the American Heart Association recently by using the "Life's Essential 8" (LE8) score. We aimed to investigate the associations of baseline and longitudinal CVH status measured by the new LE8 score (except for blood pressure) with the risk of hypertension.

方法

A total of 52 990 participants with complete data on LE8 metrics and without hypertension were enrolled from the Kailuan study, Tangshan, China. The associations of incident hypertension with the overall baseline, time-updated, and time-varying CVH score (ranging 0 [lowest] to 100 [highest]), and each component of LE8, were assessed by Cox regressions.

结论

A higher CVH score assessed by new LE8 is associated with a lower risk of subsequent hypertension, especially young adults and women.

主要结果

During a median follow-up of 10.73 years 28 380 cases of incident hypertension were identified. The risk of hypertension attenuated with increased CVH score (Ptrend< 0.0001), the hazard ratios (HRs) in high CVH versus low CVH group was 0.54 (95% confidence interval [CI], 0.51-0.57) for baseline CVH, 0.47 (95% CI, 0.45-0.50) for time-updated CVH, and 0.59 (95% CI, 0.55-0.63) for time-varying CVH. The predictive value of CVH in predicting hypertension improved by using LE8 than using Life's Simple 7 metrics. Among LE8 components, body mass index score was the strongest risk factor for hypertension. Subgroup analyses showed that the benefit of a higher CVH score on hypertension was more prominent in young adults and in women (Pinteraction< 0.05).