Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Baseline and longitudinal cardiovascular health using Life's Essential 8 metrics with the risk of incident hypertension
First author：Xue Tian ,Jingxuan Feng
Corresponding author：Anxin Wang
essential_information
- Person in charge：Xue Tian ,Jingxuan Feng
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20230193
- Published time：2023-11-30
2023-11-30
Published articles
Journal：CLINICAL AND EXPERIMENTAL HYPERTENSION
Publication type: Original Contributions
IF(IF): 12.3
PMID: 37983187 Link To Pubmed Full text Download
Background And Purpose
The quantification of cardiovascular health (CVH) was updated by the American Heart Association recently by using the "Life's Essential 8" (LE8) score. We aimed to investigate the associations of baseline and longitudinal CVH status measured by the new LE8 score (except for blood pressure) with the risk of hypertension.
Method
A total of 52 990 participants with complete data on LE8 metrics and without hypertension were enrolled from the Kailuan study, Tangshan, China. The associations of incident hypertension with the overall baseline, time-updated, and time-varying CVH score (ranging 0 [lowest] to 100 [highest]), and each component of LE8, were assessed by Cox regressions.
Conclusion
A higher CVH score assessed by new LE8 is associated with a lower risk of subsequent hypertension, especially young adults and women.
Main results
During a median follow-up of 10.73 years 28 380 cases of incident hypertension were identified. The risk of hypertension attenuated with increased CVH score (Ptrend< 0.0001), the hazard ratios (HRs) in high CVH versus low CVH group was 0.54 (95% confidence interval [CI], 0.51-0.57) for baseline CVH, 0.47 (95% CI, 0.45-0.50) for time-updated CVH, and 0.59 (95% CI, 0.55-0.63) for time-varying CVH. The predictive value of CVH in predicting hypertension improved by using LE8 than using Life's Simple 7 metrics. Among LE8 components, body mass index score was the strongest risk factor for hypertension. Subgroup analyses showed that the benefit of a higher CVH score on hypertension was more prominent in young adults and in women (Pinteraction< 0.05).