Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of obesity with cardiovascular disease in the absence of traditional risk factors
First author：Hui Luo
Corresponding author：Anxin Wang
essential_information
- Person in charge：Hui Luo
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20230196
- Published time：2023-11-08
2023-11-08
Published articles
Journal：INTERNATIONAL JOURNAL OF OBESITY
Publication type: Original Contributions
IF(IF): 4.9
PMID: 37938287 Link To Pubmed Full text Download
Background And Purpose
The association between obesity and cardiovascular disease (CVD) in people without traditional CVD risk factors is unclear. This study aimed to investigate the association of obesity with CVD and its subtypes in people without traditional CVD risk factors.
Method
Based on the Kailuan cohort study, the included participants were divided into different groups according to levels of body mass index (BMI) and waist height ratio (WHtR), respectively. Multivariate Cox proportional hazard models were used to evaluate the associations.
Conclusion
We found that obesity increased the risk of CVD in people without traditional CVD risk factors. The association of WHtR with CVD was stronger in people under 60 years old.
Main results
This study included 31,955 participants [men 63.99%; mean age (48.14 ± 3.33) years]. During a median follow-up period of 12.97 (interquartile range: 12.68-13.17) years, 1298 cases of CVD were observed. Compared with the normal BMI group, the hazard ratios (HRs) for CVD, stroke, and myocardial infarction (MI) in the BMI obese group were 1.31 (95% confidence interval [CI] 1.11-1.55), 1.21 (95%CI 1.01-1.46), 1.62 (95%CI 1.13-2.33), respectively. Compared with the WHtR non-obese group, the HRs for CVD, stroke, and MI in the obese group were 1.25(95%CI 1.11-1.41), 1.18 (95%CI 1.03-1.34), 1.57 (95%CI 1.18-2.09), respectively. There was an interaction between age and WHtR (P for interaction was 0.043). The association between WHtR and CVD was stronger in people under 60 years old, with a HR of 1.44 (95%CI 1.24-1.67).