Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Temporal relationship between arterial stiffness and blood pressure variability and joint effect on cardiovascular disease
First author：Xue Tian
Corresponding author：Anxin Wang
essential_information
- Person in charge：Xue Tian
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20240005
- Published time：2023-12-26
2023-12-26
Published articles
Journal：HYPERTENSION RESEARCH
Publication type: Original Contributions
IF(IF): 5.4
PMID: 38145991 Link To Pubmed Full text Download
Background And Purpose
Although arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) and blood pressure (BP) significantly correlated, the relationship between baPWV and BP variation (BPV) was unclear. This study aimed to examine the temporal relationship between brachial-ankle pulse wave velocity (baPWV) and systolic blood pressure variation (SBPV) and their joint effect on the development of cardiovascular disease (CVD).
Method
This study included 6632 participants with repeated assessments of baPWV and BP during 2006 to 2018. The baseline and follow-up SBPV was calculated as absolute SBP difference divided by mean SBP over sequential visits, using data between 2006-2010 and 2014-2018, respectively. Cross-lagged analysis was used to assess the temporal relation between baPWV and SBPV, and logistic analysis was used to assess the joint effect of baPWV and SBPV on CVD.
Conclusion
The findings suggested that arterial stiffness appeared to precede the increase in SBPV and their joint effect is predictive of the development of CVD.
Main results
After adjustment for confounder, the path coefficient from baseline baPWV to follow-up SBPV (β1= 0.040; P = 0.0012) was significantly had greater than the path from baseline SBPV to follow-up baPWV (β2= 0.009; P = 0.3830), with P = 0.0232 for the difference between β1and β2. This unidirectional relationship from baseline baPWV to follow-up SBPV was consistent in patients without hypertension, with isolated systolic, high systolic and diastolic, uncontrolled and controlled hypertension. In addition, participants with high levels of baseline baPWV and follow-up SBPV had greater risk of CVD (odds ratio, 5.82; 95% confidence interval, 2.50-12.60) than those with low-low levels.