Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Changes in baPWV and the risk of clinical outcomes: a cohort study of Chinese community-based population
First author：Yingting Zuo
Corresponding author：Anxin Wang
essential_information
- Person in charge：Yingting Zuo
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20240043
- Published time：2024-02-27
2024-02-27
Published articles
Journal：JOURNAL OF HUMAN HYPERTENSION
Publication type: Original Contributions
IF(IF): 2.7
PMID: 38413723 Link To Pubmed Full text Download
Background And Purpose
It has not been fully investigated whether improved arterial stiffness (AS) can reduce the clinical outcomes risk in community population-based study.
Method
In this prospective study, a total of 5247 individuals with abnormal AS (at baseline) and repeated brachial-ankle pulse wave velocity (baPWV) measurement before 2018 years were enrolled from the Kailuan Study. According the second baPWV measurement, we divided the participants into two groups, improved AS (defined as transfer elevated AS status to normal) and persistent AS (defined as maintaining elevated AS status). The outcome was a composite event of stroke, myocardial infraction, and all-cause mortality. We used Cox proportional hazards regression to examine the association between AS status at the follow-up and the subsequent outcome.
Conclusion
In conclusion, improving AS status may reduce the risk of clinical events. In the future, more research should be performed to explore the target for improving the AS status.
Main results
During a median of 5.2 years follow-up, we observed 413 end point events. After adjusted for potential confounders, comparing with the persistent AS group, individuals in the improved AS group had a 43% (hazard ratio [HR], 0.57; 95% confidence interval [CI] 0.35-0.94) decreased the risk of the primary composite events. We also found a baPWV decrease of 1 m/s was associated with a 3% decreased risk (HR, 0.97; 95% CI 0.94-0.99) for primary composite events. We further demonstrated that younger than 60 years, non-smoker, non-hypertension, and non-diabetes were associated with improved the AS status.