Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI
First author：Jing Jing,Zhang Zhe,Su Lei
Corresponding author：Tian Decai
essential_information
- Person in charge：Jing Jing,Zhang Zhe,Su Lei
- Data Sources： OTHERS
- Number of papers：OTHERS20240046
- Published time：2024-03-08
2024-03-08
Published articles
Journal：Journal of Neurology, Neurosurgery and Psychiatry
Publication type: Original Contributions
IF(IF): 11.1
PMID: 38453475 Link To Pubmed Full text Download
Background And Purpose
Background Although trigeminal nerve involvement is a characteristic of multiple sclerosis (MS), its prevalence across studies varies greatly due to MRI resolution and cohort selection bias. The mechanism behind the site specificity of trigeminal nerve injury is still unclear. We aim to determine the prevalence of trigeminal nerve involvement in patients with MS in a consecutive 7T brain MRI cohort.
Method
Methods This observational cohort originates from an ongoing China National Registry of Neuro-Inflammatory Diseases. Inclusion criteria were the following: age 18 years or older, diagnosis of MS according to the 2017 McDonald criteria and no clinical relapse within the preceding 3 months. Each participant underwent 7T MAGNETOM Terra scanner (Siemens, Erlangen, Germany), using a 32-channel phased array coil at Beijing Tiantan Hospital. T1-weighted magnetisation-prepared rapid acquisition gradient echoes, fluid-attenuated inversion recovery (FLAIR) and fluid and white matter suppression images were used to identify lesions. FLAIR* and T2* weighted images were used to identify central vein sign (CVS) within the trigeminal lesions.
Conclusion
Conclusion In this 7T MRI cohort, the prevalence of trigeminal nerve involvement was 15.8%. Characteristic CVS was detected in 26.9% of lesions in REZ. This suggests an inflammatory demyelination mechanism of trigeminal nerve involvement in MS.
Main results
Results 120 patients underwent 7T MRI scans between December 2021 and May 2023. 19/120 (15.8%) patients had a total of 45 trigeminal lesions, of which 11/19 (57.9%) were bilateral. The linear lesions extended along the trigeminal nerve, from the root entry zone (REZ) (57.8%, 26/45) to the pontine-medullary nucleus (42.2%, 19/45). 26.9% (7/26) of the lesions in REZ showed a typical central venous sign.