Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

Journal：J Am Heart Assoc

Publication type: Original Contributions

IF(IF): 5.3

PMID: 40879031 Link To Pubmed Full text Download

心脏代谢性疾病（cardiometabolic disease，CMD），包括糖尿病、心脏病和卒中，是认知功能下降的独立危险因素。心脏代谢多发病（Cardiometabolic Multimorbidity，CMM），定义为两种或两种以上心脏代谢疾病的共存。既往大多的研究仅关注单一心脏代谢疾病对认知功能的影响，很少考虑到多种疾病共存的代谢性心脏病风险分层与认知的相关关系。且CMD与2年后认知功能恶化的研究目前研究较少。C反应蛋白与心血管疾病的不良预后和死亡有关。炎症也参与CMD的发生。另外有研究发现CMD与脑白质高信号相关，小血管病变，如白质高信号、血管周围间隙扩大、腔梗等也与老年期认知功能下降相关。目前CMD认知与炎症、小血管病关系的研究很少。

Baseline participant characteristics for men and women were compared using the x2 test for categorical variables and t-tests for continuous variables. Categorical variables were presented as percentages while continuous variables were presented as mean with SD or median with interquartile range. Interaction terms were created between sex and each ASCVD risk score in multivariable linear regression models. Multivariable linear regression models, stratified by sex, were built to investigate the associations of each ASCVD risk score (i.e. continuous and categorical ASCVD risk scores) with domain and test-specific cognition Z scores. As age was accounted for in the calculations of ASCVD risk scores, this was not included as a covariate during statistical analyses. Education, marital status, income levels, Body Mass Index (BMI), drinking and baseline MoCA were adjusted for as potential confounders in the multi-adjusted model. p <0·05 was considered statistically significant. The estimated effect sizes shown as s and 95% CI were presented in the models. Statistical analyses were all performed with SAS 9·4 (SAS Institute Inc, Cary, NC).