国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Visit-to-Visit Variability of Fasting Plasma Glucose and the Risk of Cardiovascular Disease and All-Cause Mortality in the General Population

第一作者：Anxin Wang,Xiaoxue Liu,Jie Xu

通讯作者：Yilong Wang

all-cause mortality cardiovascular events death gl

基本信息

2017-11-29

已发表文章

发表杂志：Journal of the American Heart Association

发表类型: Original Contributions

影响因子(IF): 5.501

PMID: 29187392 Pubmed原文链接 全文下载

主要研究背景及目的

The association of short-term variability of fasting plasma glucose (FPG) and mortality has been well investigated. However, the relationships between visit-to-visit variability of FPG over longer periods of follow-up and cardiovascular disease (CVD) and all-cause mortality are unclear. This study aimed to investigate these relationships.

方法

The current analysis included 53 607 Chinese participants (mean age, 49.10 years) who were free of CVD in the Kailuan study. Participants were divided into 4 categories by quartiles of visit-to-visit variability of FPG. Visit-to-visit variability of FPG was defined as the coefficient of variation of 3 values of FPG that were measured from the examination periods of 2006 to 2007, 2008 to 2009, and 2010 to 2011. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for CVD and all-cause mortality.

结论

Independent of mean FPG and other baseline parameters, elevated visit-to-visit variability of FPG significantly increases the risk of CVD and all-cause mortality in the general population. Measuring long-term visit-to-visit variability of FPG is helpful for predicting the risk for CVD and all-cause mortality.

主要结果

After a mean follow-up of 4.93 years, 4261 individuals developed CVD and 1545 individuals died. The incidence of CVD and all-cause mortality was 5.04 and 5.85 per 1000 person-years, respectively. After adjusting for mean FPG and other potential confounders, individuals in the highest quartile of variability of FPG compared with participants in the lowest quartile showed a 26% greater risk of developing CVD (hazard ratio, 1.26; 95% confidence interval, 1.08–1.47) and a 46% greater risk for all-cause mortality (hazard ratio, 1.46; 95% confidence interval, 1.25–1.70).