国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Two-year changes in proteinuria and risk for myocardial infarction in patients with hypertension: a prospective cohort study
通讯作者：Yilong Wang
基本信息
- 负责人：Anxin Wang,Xiaoxue Liu
- 数据来源： Kailuan Study
- 论文编号：KAILUAN STUDY20180021
- 发表时间：2017-11-15
2017-11-15
已发表文章
发表杂志：Journal of hypertension
发表类型: Original Contributions
影响因子(IF): 4.844
PMID: 28678085 Pubmed原文链接 全文下载
主要研究背景及目的
To assess whether changes in proteinuria are associated with the incidence of myocardial infarction (MI) in patients with hypertension.
方法
The Kailuan study was a prospective longitudinal cohort study on cardiovascular risk factors and events. Hazard ratios with 95% confidence intervals (CIs) were calculated using Cox regression models.
结论
Proteinuria is associated with an increased incidence of MI, but the association is likely to be underestimated if baseline measurements of proteinuria are used. Measures of changes in proteinuria, particular persistent proteinuria, are more likely to reflect the lifetime risk for MI.
主要结果
A total of 24 926 hypertensive patients (mean age: 55.210.9 years) without previous MI were included. After a mean follow-up of 6.8 years, 382 (1.5%) individuals developed MI. Participants with proteinuria at baseline had a 60% higher risk for developing MI as compared with participants without proteinuria at baseline (hazard ratio: 1.60, 95% CI: 1.12–2.29) after adjusting for dyslipidemia, diabetes mellitus and other cardiovascular risk factors. Compared with participants without proteinuria, individuals with incident proteinuria or persistent proteinuria during the follow-up had 54 and 141% higher risks for developing MI, respectively (hazard ratio: 1.54, 95% CI: 1.14–2.09 and hazard ratio: 2.41, 95% CI: 1.59–3.66; all P<0.05).