Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Two-Year Changes in Proteinuria and the Risk of Stroke in the Chinese Population: A Prospective Cohort Study
First author：Anxin Wang,Xiaoxue Liu
Corresponding author：Yilong Wang
essential_information
- Person in charge：Anxin Wang,Xiaoxue Liu
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20180023
- Published time：2017-06-30
2017-06-30
Published articles
Journal：Journal of the American Heart Association
Publication type: Original Contributions
IF(IF): 5.501
PMID: 28666989 Link To Pubmed Full text Download
Background And Purpose
Whether changes in proteinuria are associated with incident stroke in the general population is unclear. This study aimed to investigate the association between changes in proteinuria and incident stroke and its subtypes.
Method
The current study included 60 940 Chinese participants (mean age, 50.69 years) who were free of stroke at the time of surveys (2006–2007 and 2008–2009). Participants were divided into 4 categories according to 2-year changes in proteinuria: no proteinuria, remittent proteinuria, incident proteinuria, and persistent proteinuria. Cox proportional hazards models were used to calculate hazard ratios and their 95% CIs for stroke.
Conclusion
Changes in proteinuria exposure, particularly persistent proteinuria, are more likely to reflect the risk of stroke, compared with proteinuria collected at a single time point in the general population.
Main results
After a median follow-up period of 6.92 years, 1769 individuals developed stroke. After adjustment for confounding factors, incident proteinuria and persistent proteinuria were associated with increased risk of stroke (hazard ratio, 1.46 [95% CI, 1.26–1.68] and hazard ratio, 1.71 [95% CI, 1.42–2.06], respectively) compared with no proteinuria, which were higher than proteinuria detected at one single point (hazard ratio, 1.25; 95% CI, 1.09–1.43). The effect size for risk of stroke subtypes including ischemic stroke and hemorrhagic stroke was similar.