国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between polyvascular atherosclerosis and estimated glomerular filtration rate in patients with ischaemic stroke: data analysis of the patients in the Chinese National Stroke Registry

第一作者：Xia Meng,Yu Chen

通讯作者：Yilong Wang

Atherosclerosis Chronic kidney disease Estimated g

基本信息

2015-04-21

已发表文章

发表杂志：Neurological Research

发表类型: Original Contributions

影响因子(IF): 2.448

PMID: 25896168 Pubmed原文链接 全文下载

主要研究背景及目的

This study evaluated the prevalence of chronic kidney disease (CKD) in ischemic stroke (IS) patients with polyvascular disease (PolyVD) and analysed the relationship between PolyVD and estimated glomerular filtration rate (eGFR) in IS patients.

方法

Data from 9152 consecutive IS patients from the China National Stroke Registry were analysed. PolyVD was defined as patients with IS and coronary artery disease (CAD) and/or peripheral arterial disease. (PAD). Chronic kidney disease was defined as eGFR v60 mL/minute/1.73 m2.The prevalence of CKD in IS patients with PolyVD was calculated. Logistic regression was used to estimate the correlation between PolyVD and eGFR between the monovascular group (IS alone) and the PolyVD group after adjusting for age, current or previous smoking, moderate or heavy drinking, body mass index, hypertension, dyslipidemia,diabetes mellitus, atrial fibrillation, previous stroke, and National Institutes of Health Stroke Scale scores.

结论

IS patients with PolyVD had a high prevalence of CKD, and PolyVD was independently ssociated with a low eGFR.

主要结果

PolyVD was observed in 1387 of 9152 patients (15.16%). Among these patients, 1351 (14.76%) had CAD, 56 (0.61%) had PAD, and 20 (0.22%) had CAD and PAD in addition to IS. The prevalence of CKD in IS patients with PolyVD and IS alone was 29.56 and 16.28%, respectively (Pv0.0001). The PolyVD group had a significantly higher risk of lower eGFR (OR: 1.414, 95% CI: 1.202–1.665,Pv0.0001) compared with patients with IS alone.