Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The design, rationale, and baseline characteristics of a nationwide cohort registry in China: blood pressure and clinical outcome in TIA or ischemic stroke
First author：Jie Xu,Yi Liu
Corresponding author：Yilong Wang,Aoshuang Yan
essential_information
- Person in charge：Jie Xu,Yi Liu
- Data Sources： BOSS
- Number of papers：BOSS20180070
- Published time：2016-10-01
2016-10-01
Published articles
Journal：Patient Preference and Adherence
Publication type: Original Contributions
IF(IF): 2.711
PMID: 27942205 Link To Pubmed Full text Download
Background And Purpose
The relationship between poststroke blood pressure (BP) and clinical outcomes in ischemic stroke (IS) is still controversial. However, there is no large BP database for IS or transient ischemic attack (TIA) in China. This study aims to describe the rationale, study design, and baseline characteristics of a nationwide BP database in IS or TIA patients in China.
Method
The BOSS (blood pressure and clinical outcome in TIA or ischemic stroke) study was a hospital-based, prospective cohort study aiming to assess BP parameters and clinical outcome in IS/TIA patients. BP parameters were based on office BP, ambulatory BP, and home BP. Clinical outcomes included stroke recurrence, combined vascular events, and disability. Electronic case-report forms were used to record baseline and follow-up data. The patients were followed up for clinical outcomes at 3 months through face-to-face interview and at 12 months by telephone.
Conclusion
The BOSS registry will provide important evidence about BP management in the acute phase and secondary prevention for IS/TIA patients.
Main results
Between October 2012 and February 2014, the BOSS registry recruited 2,608 patients from 61 hospitals, with a mean age of 62.5 years, 32.4% of whom were female, 88.9% with an entry diagnosis of IS, and 86% diagnosed with hypertension. The rates of patients lost-to-follow-up were 3.1% at 3 months and 5.1% at 1 year; 93% of patients completed ambulatory BP monitoring during hospitalization and 94.7% finished a 3-month BP diary.