国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study.

第一作者：Anxin Wang

通讯作者：Shouling Wu

All-Cause Mortality Cumulative Resting Heart Rate

基本信息

  • 负责人：Anxin Wang
  • 数据来源： Kailuan Study
  • 论文编号：KAILUAN STUDY20180079
  • 发表时间：2017-01-09

2017-01-09

已发表文章

发表杂志：Scientific Reports

发表类型: Original Contributions

影响因子(IF): 4.379

PMID: 28067310 Pubmed原文链接 全文下载

主要研究背景及目的

The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population.In the current analysis, we used data from the baseline to the third examination in the Kailuan cohort study to calculate the cumRHR and to explore the association between cumRHR, the number of visits with a higher RHR and any cause of death. We also test whether there were sex-related differences. We hypothesise that higher cumRHR and the number of visits with a higher RHR are associated with a higher risk of all-cause mortality.

方法

In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted

结论

In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality.

主要结果

During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07-1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23-1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33-2.61) of mortality.