Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study.
First author：Anxin Wang
Corresponding author：Shouling Wu
essential_information
- Person in charge：Anxin Wang
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20180079
- Published time：2017-01-09
2017-01-09
Published articles
Journal：Scientific Reports
Publication type: Original Contributions
IF(IF): 4.379
PMID: 28067310 Link To Pubmed Full text Download
Background And Purpose
The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population.In the current analysis, we used data from the baseline to the third examination in the Kailuan cohort study to calculate the cumRHR and to explore the association between cumRHR, the number of visits with a higher RHR and any cause of death. We also test whether there were sex-related differences. We hypothesise that higher cumRHR and the number of visits with a higher RHR are associated with a higher risk of all-cause mortality.
Method
In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted
Conclusion
In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality.
Main results
During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07-1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23-1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33-2.61) of mortality.