国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
THRIVE- c score predicts clinical outcomes in Chinese patients after thrombolysis
基本信息
- 负责人：Yuesong Pan,Yujing Peng
- 数据来源： TIMS-CHINA
- 论文编号：TIMS-CHINA20180083
- 发表时间：2018-01-30
2018-01-30
已发表文章
主要研究背景及目的
Total Health Risks in Vascular Events‐calculation score (THRIVE‐c) is an easy use and patient‐specific outcome predictive score by computing the logistic equation with patients’ continuous variables. We validated its performance in Chinese ischemic stroke patients receiving intravenous thrombolysis (IVT) therapy.
方法
We used data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS‐China) registry to validate the THRIVE‐c score in patients receiving IVT therapy. We evaluated the score performance using area under the receiver operating characteristic curve (AUC). Receiver operator characteristic curve (ROC) was used to compare THRIVE‐c score performance with other scores in predicting clinical outcome and symptomatic intracranial hemorrhage (SICH). Calibration was assessed by Pearson correlation coefficient and Hosmer–Lemeshow test.
结论
The THRIVE‐c score reliably predicts the risks of 3‐month SICH, poor functional outcome, and mortality after IVT therapy in Chinese patients with ischemic stroke.
主要结果
Among the 1,128 patients receiving IVT therapy included in this study, AUC of the THRIVE‐c score for 3‐month SICH, poor functional outcome, and mortality rate was 0.70 (95% CI: 0.63–0.76), 0.75 (95% CI: 0.73–0.78) and 0.81 (95% CI: 0.77–0.85), respectively. The increased THRIVE‐c score was associated with higher risk of developing SICH, poor functional outcome, or mortality in patients with acute ischemic stroke at 3 months after thrombolysis. The performance of the THRIVE‐c score was similar to or superior to other predictive scores (THRIVE score, SEDAN score, DRAGON score, HIAT2 score).