国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA.
第一作者：Yuesong Pan
通讯作者：Yilong Wang
基本信息
- 负责人：Yuesong Pan
- 数据来源： CHANCE
- 论文编号：CHANCE20180086
- 发表时间：2016-09-09
2016-09-09
已发表文章
主要研究背景及目的
To investigate whether abnormal glucose regulation contributes to a new stroke in patients with a minor ischemic stroke or TIA
方法
We derived data from the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 3 groups: patients with diabetes mellitus (DM), impaired fasting glucose (IFG), and normal fasting plasma glucose. The primary outcome was a new stroke (ischemic or hemorrhagic) at 90 days. We assessed the association between glucose regulation status and risk of stroke by multivariable Cox regression models adjusted for potential covariates
结论
Both IFG and DM were associated with an increased risk of stroke in patients with a minor stroke or TIA.
主要结果
Among 5,135 included patients, 1,587 (30.9%), 409 (8.0%), and 3,139 (61.1%) patients were identified as DM, IFG, and normal glucose, respectively. Compared with normal glucose, IFG (11.0% vs 6.9%; adjusted hazard ratio [adj HR] 1.57, 95% confidence interval [CI] 1.13–2.19) and DM (15.8% vs 6.9%; adj HR 2.38, 95% CI 1.97–2.88) were associated with increased risk of stroke at 3 months after a minor stroke or TIA after adjusted for potential covariates. We found a weak J-shaped association between fasting plasma glucose and risk of stroke with a nadir of 4.9 mmol/L.