Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA.
First author：Yuesong Pan
Corresponding author：Yilong Wang
essential_information
- Person in charge：Yuesong Pan
- Data Sources： CHANCE
- Number of papers：CHANCE20180086
- Published time：2016-09-09
2016-09-09
Published articles
Journal：Neurology
Publication type: Original Contributions
IF(IF): 9.91
PMID: 2016; 87:1551-1556 Link To Pubmed Full text Download
Background And Purpose
To investigate whether abnormal glucose regulation contributes to a new stroke in patients with a minor ischemic stroke or TIA
Method
We derived data from the Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 3 groups: patients with diabetes mellitus (DM), impaired fasting glucose (IFG), and normal fasting plasma glucose. The primary outcome was a new stroke (ischemic or hemorrhagic) at 90 days. We assessed the association between glucose regulation status and risk of stroke by multivariable Cox regression models adjusted for potential covariates
Conclusion
Both IFG and DM were associated with an increased risk of stroke in patients with a minor stroke or TIA.
Main results
Among 5,135 included patients, 1,587 (30.9%), 409 (8.0%), and 3,139 (61.1%) patients were identified as DM, IFG, and normal glucose, respectively. Compared with normal glucose, IFG (11.0% vs 6.9%; adjusted hazard ratio [adj HR] 1.57, 95% confidence interval [CI] 1.13–2.19) and DM (15.8% vs 6.9%; adj HR 2.38, 95% CI 1.97–2.88) were associated with increased risk of stroke at 3 months after a minor stroke or TIA after adjusted for potential covariates. We found a weak J-shaped association between fasting plasma glucose and risk of stroke with a nadir of 4.9 mmol/L.