国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study
第一作者：Anxin Wang
通讯作者：Shouling Wu
基本信息
- 负责人：Anxin Wang
- 数据来源： APAC
- 论文编号：APAC20180092
- 发表时间：2016-11-18
2016-11-18
已发表文章
发表杂志：BMC Cardiovasc Disord
发表类型: Original Contributions
影响因子(IF): 1.832
PMID: 27863466 Pubmed原文链接 全文下载
主要研究背景及目的
Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachialankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese community population.
方法
The community-based Asymptomatic Polyvascular Abnormalities in Community study examined asymptomatic polyvascular abnormalities in a Chinese population aged ≥ 40 years. The relationship between MetS and its components and baPWV was analyzed by multivariate logistic and linear regression models.
结论
baPWV was associated with MetS and was greater with increasing numbers of MetS components. Elevated blood pressure was the most important factor for baPWV.
主要结果
Out of 5181 study participants, 1271 subjects (24.53%) had MetS. Mean values of baPWV in subjects with 0, 1, 2,3, 4, and 5 components of MetS were 1430, 1526, 1647, 1676,1740, and 1860 cm/s, respectively (p < 0.001 for trend). After adjusting for confounding risk factors, MetS was significantly associated with baPWV(odds ratio [OR]: 2.74; 95% CI: 2.28, 3.30). Among the five components of MetS, elevated blood pressure was the most important factor for baPWV. All models of multivariate linear regression analysis showed a significant positive correlation between the increasing numbers of MetS components and baPWV (p < 0.0001).