Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study
First author：Anxin Wang
Corresponding author：Shouling Wu
essential_information
- Person in charge：Anxin Wang
- Data Sources： APAC
- Number of papers：APAC20180092
- Published time：2016-11-18
2016-11-18
Published articles
Journal：BMC Cardiovasc Disord
Publication type: Original Contributions
IF(IF): 1.832
PMID: 27863466 Link To Pubmed Full text Download
Background And Purpose
Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachialankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese community population.
Method
The community-based Asymptomatic Polyvascular Abnormalities in Community study examined asymptomatic polyvascular abnormalities in a Chinese population aged ≥ 40 years. The relationship between MetS and its components and baPWV was analyzed by multivariate logistic and linear regression models.
Conclusion
baPWV was associated with MetS and was greater with increasing numbers of MetS components. Elevated blood pressure was the most important factor for baPWV.
Main results
Out of 5181 study participants, 1271 subjects (24.53%) had MetS. Mean values of baPWV in subjects with 0, 1, 2,3, 4, and 5 components of MetS were 1430, 1526, 1647, 1676,1740, and 1860 cm/s, respectively (p < 0.001 for trend). After adjusting for confounding risk factors, MetS was significantly associated with baPWV(odds ratio [OR]: 2.74; 95% CI: 2.28, 3.30). Among the five components of MetS, elevated blood pressure was the most important factor for baPWV. All models of multivariate linear regression analysis showed a significant positive correlation between the increasing numbers of MetS components and baPWV (p < 0.0001).