Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Non-High-Density Lipoprotein Cholesterol Levels on the Risk of Asymptomatic Intracranial Arterial Stenosis: A Result from the APAC Study
First author：Anxin Wang
Corresponding author：Xingquan Zhao,Shouling Wu
essential_information
- Person in charge：Anxin Wang
- Data Sources： APAC
- Number of papers：APAC20180093
- Published time：2016-11-18
2016-11-18
Published articles
Journal：Scientific reports
Publication type: Original Contributions
IF(IF): 4.379
PMID: 27857223 Link To Pubmed Full text Download
Background And Purpose
Intracranial arterial stenosis (ICAS) is an important cause of ischemic stroke and transient ischemic attack (TIA), and the correlation between the plasma non-high density cholesterol (non-HDLC) levels and ICAS, especially asymptomatic ICAS (AICAS) is not clear.
Method
The Asymptomatic Polyvascular Abnormalities Community(APAC) study is a community-based, prospective, long-term follow-up observational study. 3387 participants were enrolled in this study. The diagnosis of AICAS was made by transcranial Doppler ultrasonography. The participants were then divided into 3 groups based on their non-HDLC levels. The cox regression was used to analyze the correlation between the non-HDLC level and the incidence of AICAS.9.98% of the participants were diagnosed with AICAS during 2 years following up.
Conclusion
In conclusions, our findings suggest that elevated non-HDLC levels a significant risk factor for the development of AICAS in the APAC study.
Main results
Multivariate analysis showed that non-HDL-C is an independent indicator for the incidence of AICAS (HR = 1.22, 95%CI: 1.06-1.40), The incidence of AICAS gradually increase with the increasing non-HDLC level. Compared with subgroup(non-HDLC < 3.4 mmol/l), incidence of AICAS was significantly higher in the subgroups(non-HDLC 3.4-4.1 mmol/l and non-HDLC ≥ 4.1 mmol/l) after adjustment for the confounding factors (HR = 1.32, 95%CI:1.02-1.73; HR = 1.46, 95%CI: 1.10-1.94, respectively).