国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
hematocrit and the incidence of stroke: a prospective, population-based cohort study
第一作者：Renling Yang
基本信息
- 负责人：Renling Yang
- 数据来源： Kailuan Study
- 论文编号：KAILUAN STUDY20180103
- 发表时间：2018-10-23
2018-10-23
已发表文章
发表杂志：Therapeutics and Clinical Risk Management
发表类型: Original Contributions
影响因子(IF): 2.423
PMID: 30425503 Pubmed原文链接 全文下载
主要研究背景及目的
背景：脑卒中发病率、致死率均很高，已成为严重的公共卫生问题，识别该类疾病危险因素做好一级预防意义重大。目前国外研究发现血细胞比容与脑卒中发病具有相关性但结果不一致。 目的：本研究的目的是探索中国人群中血细胞比容水平对脑卒中发病的影响。
方法
Methods: The Kailuan study is a prospective longitudinal cohort study on risk factors and events of chronic diseases. Using a multivariable Cox proportional hazards analysis, we examined the association between baseline hematocrit values and the incidence of stroke in the Kailuan cohort (93,299 participants).
结论
Conclusion: Higher hematocrit levels are associated with a higher incidence of stroke in the Chinese population.
主要结果
Results: A total of 3,624 participants developed stroke during the 9-year follow-up period. In Cox regression models adjusted for demographic information and for clinical variables, there was a significant association between baseline hematocrit levels and the incidence of stroke. The highest hematocrit quartile (quartile 5: men, hematocrit .48.6%; women, hematocrit .43.2%) was associated with a higher incidence of stroke (HR 1.17, 95% CI 1.04–1.31, P for trend =0.0016) compared with the lowest hematocrit quartile (quartile 1: men, hematocrit ,41.5%; women, hematocrit ,36.6%). In the analysis of ischemic stroke, intracerebral hemorrhage separately, similar association was observed in ischemic stroke, but there were no statistical differences in intracerebral hemorrhage.