Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of oxLDL and LDL with outcomes of Minor Ischemic Stroke and Transient Ischemic Attack
First author：Anxin Wang,Liye Dai
Corresponding author：Xia Meng,Yongjun Wang
essential_information
- Person in charge：Anxin Wang,Liye Dai
- Data Sources： CHANCE
- Number of papers：CHANCE20180110
- Published time：2020-02-19
2020-02-19
Published articles
Journal：Atherosclerosis
Publication type: Original Article
IF(IF): 5.162
PMID: doi.org/10.1016/j.atherosclerosis.2020.02.003 Link To Pubmed Full text Download
Background And Purpose
Oxidized low-density lipoprotein (oxLDL) is an important modification of low-density lipoprotein (LDL), which are both related to atherosclerotic cardiovascular diseases. We aim to estimate the association of different combination of levels of LDL and oxLDL with the outcomes of acute minor ischemic stroke and transient ischemic attack (TIA).
Method
In the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial, a subgroup of 3019 patients with elevated baseline oxLDL and LDL levels were analyzed. Patients were divided into four groups according to different combination of LDL and oxLDL levels. The associations of LDL and oxLDL with prognosis of patients using multivariable Cox regression models.
Conclusion
ThepresenceofhighercombinedserumoxLDLandLDLlevelswasassociatedwithincreasedriskof recurrentstrokeandpoorfunctionaloutcomesinminorstrokeorhigh-riskTIApatients.