国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association of oxLDL and LDL with outcomes of Minor Ischemic Stroke and Transient Ischemic Attack

第一作者：Anxin Wang,Liye Dai

通讯作者：Xia Meng,Yongjun Wang

Minorstroke Transientischemicattack Oxidizedlowden

基本信息

2020-02-19

已发表文章

发表杂志：Atherosclerosis

发表类型: Original Article

影响因子(IF): 5.162

PMID: doi.org/10.1016/j.atherosclerosis.2020.02.003 Pubmed原文链接 全文下载

主要研究背景及目的

Oxidized low-density lipoprotein (oxLDL) is an important modification of low-density lipoprotein (LDL), which are both related to atherosclerotic cardiovascular diseases. We aim to estimate the association of different combination of levels of LDL and oxLDL with the outcomes of acute minor ischemic stroke and transient ischemic attack (TIA).

方法

In the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial, a subgroup of 3019 patients with elevated baseline oxLDL and LDL levels were analyzed. Patients were divided into four groups according to different combination of LDL and oxLDL levels. The associations of LDL and oxLDL with prognosis of patients using multivariable Cox regression models.

结论

ThepresenceofhighercombinedserumoxLDLandLDLlevelswasassociatedwithincreasedriskof recurrentstrokeandpoorfunctionaloutcomesinminorstrokeorhigh-riskTIApatients.

主要结果