国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：Scientific Reports

发表类型: Original Contributions

影响因子(IF): 4.379

PMID: unknown Pubmed原文链接 全文下载

Peripheral artery disease (PAD) is one of the most common atherosclerotic diseases around the world. It usually refers the lower limb artery atherosclerosis, which is the arteries distal to the aortic bifurcation. In recent decades, the morbidity of PAD increases by about one-quarter to approximately 200 million patients, especially in the older population. The prevalence increases with age from around 10% at age 65 years to 20% at age >=75 years. In China, the prevalence in five surveys of populations with average ages 60–70 years varied between 2.5% and 6.9% in men and 1.7% and 10.4% in women[2]. Patients with PAD have an increased risk of cardiovascular diseases and poor prognosis. In our study we aimed to find out the predictive value of ICVH to the occurrence of PAD and analysis the specific characteristics among the seven ICVH metrics in the atherosclerotic disease in Chinese population.

A prospective cohort study.The Asymptomatic Polyvascular Abnormalities Community study (APAC) is a community-based, prospective, long-term follow-up observational study, to investigate the epidemiology of asymptomatic polyvascular abnormalities in Chinese adult. The study cohort was a sub-population of a previously described population of the Kailuan study[10]. From June 2010 to June 2011, a sample of 7000 subjects older than 40 years was randomly selected from the Kailuan cohort, and the selected method has been descripted in our previous published protocol. A total of 5440 participants with no history of stroke, transient ischemic attack, and coronary disease at baseline as assessed by a validated questionnaire were included in our final APAC study. The first time follow- up visit was taken from 2012 to 2013, which is two years after the baseline visit. During the follow-up visit, we excluded 184 participants who were diagnosed PAD in the baseline and 103 participants who did not finish the follow-up visit in out study, and 1155 participants did not measure the ABI values this time. What is more, 82 other participants were excluded in our study because of the poorly compressible leg arteries as the elevated ABI values were ≥1.40. Finally, 3916 participants were included in this study. The study was performed according to the guidelines from the Helsinki Declaration and was approved by the Ethics Committees of the Kailuan General Hospital and the Beijing Tiantan Hospital. Written informed consent was obtained from all participants.