国家神经系统疾病临床医学研究中心数据管理与共享系统

发表杂志：The Journal of Clinical Hypertension

发表类型: Original Contributions

影响因子(IF): 2.63

PMID: 29624861 Pubmed原文链接 全文下载

Studies demonstrated that a decreased level of kidney function is an independent risk factor for all-cause mortality as well as adverse cardiovascular disease outcomes including myocardial infarction, stroke, and progression of heart failure. As an important marker of chronic kidney disease (CKD), proteinuria was proved to be associated with incident stroke during the last few decades. Data suggested that baseline proteinuria confers a 50%-92% greater risk of future stroke. Previous study demonstrated that the prevalence of proteinuria was higher in the hypertensive group than in the normotensive group (hypertensive group, 33.9%; normotensive, 10%). Furthermore, data from the China National Stroke Screening Survey (CNSSS) showed that hypertension ranked in first place among factors contributing to stroke in China. The association between proteinuria and stroke, in particular, should be noted in the hypertensive population who are at high risk for the development of stroke. More important, proteinuria often changes dynamically, showing regression or progression. However, an inherent limitation of previous studies is the reliance on a single time point by which to assess kidney damage and events using baseline proteinuria. The value of multiple dipstick measurements for changes in proteinuria and its relation with stroke outcomes has rarely been investigated. Therefore, we conducted this study to assess the relationship between proteinuria change and stroke incidence in participants with hypertension.

This study examined whether proteinuria changes across 2-year assessments were associated with incident stroke in individuals with hypertension.We used visit data from 24 300 participants with hypertension of the Kailuan study who were stroke free at baseline. Based on the baseline and 2-year dipstick screening results, participants were classified as having no, remittent, incident, or persistent proteinuria.