国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

External validation of the prestroke independence, sex, age, national institutes of health stroke scale score for predicting pneumonia after stroke using data from the china national stroke registry.

第一作者：Runhua Zhang

通讯作者：Yongjun Wang,Yilong Wang

Stroke pneumonia ISAN score intracerebral hemorrha

基本信息

  • 负责人：Runhua Zhang
  • 数据来源： CNSR-I
  • 论文编号：CNSR-I20190042
  • 发表时间：2017-05-01

2017-05-01

已发表文章

发表杂志：Journal of Stroke and Cerebrovascular Diseases

发表类型: Original Contributions

影响因子(IF): 1.598

PMID: 27988203 Pubmed原文链接 全文下载

主要研究背景及目的

Pneumonia is an important risk factor for mortality and morbidity after stroke. The Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN) score was shown to be a useful tool for predicting stroke-associated pneumonia based on UK multicenter cohort study. We aimed to externally validate the score using data from the China National Stroke Registry (CNSR).

方法

Eligible patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) in the CNSR from 2007 to 2008 were included. The area under the receiver operating characteristic (AUC) curve was used to evaluate discrimination. The Hosmer–Lemeshow goodness of fit test and Pearson correlation coefficient were performed to assess calibration of the model.

结论

The ISAN score was a useful tool for predicting in-hospital pneumonia after acute stroke, especially for patients with AIS. Further validations need to be done in different populations.

主要结果

A total of 19,333 patients (AIS = 14400; ICH = 4933) were included and the overall pneumonia rate was 12.7%. The AUC was .76 (95% confidence interval [CI]: .75-.78) for the subgroup of AIS and .70 (95% CI: .68-.72) for the subgroup of ICH. The Hosmer-Lemeshow test showed the ISAN score with the good calibration for AIS and ICH (P = .177 and .405, respectively). The plot of observed versus predicted pneumonia rates suggested higher correlation for patients with AIS than with ICH (Pearson correlation coefficient = .99 and .83, respectively).