Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Alkaline Phosphatase and Outcomes in Patients with Preserved Renal Function: Results from China National Stroke Registry
First author：Lixia Zong,Xianwei Wang
Corresponding author：Yilong Wang,Yongjun Wang
essential_information
- Person in charge：Lixia Zong,Xianwei Wang
- Data Sources： CNSR-I
- Number of papers：CNSR-I20190044
- Published time：2018-04-18
2018-04-18
Published articles
Journal：Stroke
Publication type: Original Contributions
IF(IF): 7.914
PMID: 29669879 Link To Pubmed Full text Download
Background And Purpose
Alkaline phosphatase (ALP) is associated with risk of adverse cardiovascular events in patients with kidney failure. However, there is little data about effects of ALP on stroke outcomes in patients with preserved kidney function. The study aimed to explore the association between serum ALP level and clinical outcomes after stroke in patients with preserved kidney function.
Method
We included 16,367 stroke patients with preserved kidney function from the China National Stroke Registry for current analysis. Serum ALP levels were tested by automated enzymatic method using unfrozen samples in each center. Participants were divided into five groups according to ALP quintiles. Composite endpoint is comprised of recurrent stroke, myocardial infarction, other ischemic vascular events and all-cause mortality. Poor functional outcome is defined as modified Rankin scale of 3-6. Multivariable logistic regression was used to evaluate the independent association of serum ALP with one-year all-cause mortality, recurrent stroke, composite endpoint and poor functional outcome.
Conclusion
In patients with preserved kidney function, ALP may be an independent predictor of all-cause mortality, stroke recurrence, composite endpoint and poor functional outcome after stroke.
Main results
The mean age of the included 16,367 patients was 63.9 years old, and 63.3% of them were men. Among the top ALP quintile (>98.0 U/L), one-year incidences of all-cause mortality, recurrent stroke, composite endpoint and poor functional outcome were 12.6%, 5.7%, 14.4% and 27.0% respectively. Compared with the lowest ALP quintile (≤59.0 U/L), the adjusted odds ratios of the top quintile were 1.36 (1.10-1.68) for all-cause mortality, 1.45 (1.11-1.90) for stroke recurrence, 1.35 (1.12-1.63) for composite endpoint, and 1.36 (1.17-1.60) for poor functional outcome. There was no significant interaction between age, sex or alcohol consumption and ALP (p for interaction ≥ 0.10) for all outcomes.