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The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: Decreased glial activation
First author：Haoxiao Chang,Yuzhen Wei
Corresponding author：Linlin Yin
essential_information
- Person in charge：Haoxiao Chang,Yuzhen Wei
- Data Sources： OTHERS
- Number of papers：OTHERS20190050
- Published time：2019-02-14
2019-02-14
Published articles
Journal：Behavioural Brain Research
Publication type: Original Contributions
IF(IF): 3.332
PMID: 30772428 Link To Pubmed Full text Download
Background And Purpose
Cuprizone (CPZ), a copper chelator that has been shown to selectively damage white matter, can induce a novel animal model to mimic some symptoms of schizophrenia. This study aimed to examine the effect of clozapine (CLZ) on behavioural changes induced by CPZ exposure and try to explore the underlying mechanisms.
Method
Behavioural abnormalities associated with feeding mice a 0.4% (w/w) CPZ-containing diet were assessed by Ymaze, spontaneous locomotor activity, and climbing tests. CLZ treatment reversed the increase in total explored distance, exploring velocity, locomotor movements, climbing behaviours and glial activation induced by CPZ exposure.
Conclusion
Our findings indicate that increased glial activation may be related to behavioural abnormalities in CPZ exposure mice and that anti-inflammatory properties may be involved in the CLZ mechanisms. CPZ shortterm exposure with a higher dosage may offer a useful model to study some aspects of schizophrenia and evaluate the efficacy of antipsychotics.
Main results
Our findings indicate that increased glial activation may be related to behavioural abnormalities in CPZ exposure mice and that anti-inflammatory properties may be involved in the CLZ mechanisms. CPZ shortterm exposure with a higher dosage may offer a useful model to study some aspects of schizophrenia and evaluate the efficacy of antipsychotics.