国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: Decreased glial activation

第一作者：Haoxiao Chang,Yuzhen Wei

通讯作者：Linlin Yin

Schizophrenia; Cuprizone; Behaviour abnormality; C

基本信息

2019-02-14

已发表文章

发表杂志：Behavioural Brain Research

发表类型: Original Contributions

影响因子(IF): 3.332

PMID: 30772428 Pubmed原文链接 全文下载

主要研究背景及目的

Cuprizone (CPZ), a copper chelator that has been shown to selectively damage white matter, can induce a novel animal model to mimic some symptoms of schizophrenia. This study aimed to examine the effect of clozapine (CLZ) on behavioural changes induced by CPZ exposure and try to explore the underlying mechanisms.

方法

Behavioural abnormalities associated with feeding mice a 0.4% (w/w) CPZ-containing diet were assessed by Ymaze, spontaneous locomotor activity, and climbing tests. CLZ treatment reversed the increase in total explored distance, exploring velocity, locomotor movements, climbing behaviours and glial activation induced by CPZ exposure.

结论

Our findings indicate that increased glial activation may be related to behavioural abnormalities in CPZ exposure mice and that anti-inflammatory properties may be involved in the CLZ mechanisms. CPZ shortterm exposure with a higher dosage may offer a useful model to study some aspects of schizophrenia and evaluate the efficacy of antipsychotics.

主要结果

Our findings indicate that increased glial activation may be related to behavioural abnormalities in CPZ exposure mice and that anti-inflammatory properties may be involved in the CLZ mechanisms. CPZ shortterm exposure with a higher dosage may offer a useful model to study some aspects of schizophrenia and evaluate the efficacy of antipsychotics.