Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Neutrophil counts, neutrophil ratio and new stroke in minor ischemic stroke or TIA
First author：Bihong Zhu,Yuesong Pan
Corresponding author：Yongjun Wang,Yilong Wang
essential_information
- Person in charge：Bihong Zhu,Yuesong Pan
- Data Sources： CHANCE
- Number of papers：CHANCE20190057
- Published time：2018-03-22
2018-03-22
Published articles
Journal：Neurology
Publication type: Original Contributions
IF(IF): 9.91
PMID: 29678934 Link To Pubmed Full text Download
Background And Purpose
Evidence about whether neutrophil counts or neutrophil ratio is associated with new stroke is scant. The aim of this study is to assess the association of neutrophil counts or neutrophil ratio with a new stroke in patients with minor stroke or TIA.
Method
We derived data from the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorized into 4 groups according to the quartile of neutrophil counts or neutrophil ratio. The primary outcome was a new stroke (ischemic or hemorrhagic), and secondary outcomes included a new composite vascular event (stroke, myocardial infarction, or death resulting from cardiovascular causes) and ischemic stroke during the 90-day follow-up. We assessed the association between neutrophil counts, neutrophil ratio, and risk of new stroke.
Conclusion
High levels of both neutrophil counts and neutrophil ratio were associated with an increased risk of new stroke, composite events, and ischemic stroke in patients with a minor ischemic stroke or TIA.
Main results
A total of 4,854 participants were enrolled, among whom 495 had new strokes at 90 days. Compared with the first quartile, the second, third, and fourth quartiles of neutrophil counts were associated with increased risk of new stroke (adjusted hazard ratio 1.40 [95% confidence interval (CI) 1.05–1.87], 1.55 [95% CI 1.17–2.05], and 1.69 [95% CI 1.28–2.23], respectively, p for trend <0.001). Similar results were observed for the endpoint of composite events and ischemic stroke. Parallel results were found for neutrophil ratio.