Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of visit-to- visit blood pressure variability with the risk of all-cause mortality and cardiovascular events in general population
First author：Liye Dai
Corresponding author：Yongun Wang
essential_information
- Person in charge：Liye Dai
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20190063
- Published time：2017-11-16
2017-11-16
Published articles
Journal：J Clin Hypertens
Publication type: Original Contributions
IF(IF): 3.738
PMID: 29457332 Link To Pubmed Full text Download
Background And Purpose
The association between blood pressure variability (BPV) and the risk of all-cause mortality and cardiovascular diseases (CVD) is not well understoodIn this study, we performed a prospective cohort study to examine the potential associations between BP variability and the risk of all-cause mortality and CVD in the Chinese general population.
Method
The Kailuan study is a prospective longitudinal cohort study on cerebrovascular events and cardiovascular factors. In this study, resting blood pressure was measured at baseline and every 2 years from 2006 to 2007. BPV is mainly defined as the coefficient of variation (CV). Hazard ratio (HR), with 95% confidence intervals (CI) was calculated using Cox regression model.
Conclusion
We concluded that visit-to- visit BPV was associated with all-cause death and cardiovascular and cerebrovascular events in Chinese general population.
Main results
Among 52 387 participants, we identified 1817 who ended up with all-cause death and 1198 with CVD. Each 4.68% increase in BPV was associated with a 13% increase in the risk of mortality (HR = 1.13, 95% CI = 1.09-1.18) and a 7% increase in CVD (HR = 1.07, 95% CI = 1.02-1.13), respectively. After adjustment of confounding factors, the HR of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure (SBP) was 1.37 (1.19, 1.57) for all-cause death, 1.18 (1.01, 1.39) for CVD. Similar results were also observed when BPV was measured by different parameters.